Beijing/W genotype Mycobacterium tuberculosis and drug resistance.

2.50
Hdl Handle:
http://hdl.handle.net/10029/7598
Title:
Beijing/W genotype Mycobacterium tuberculosis and drug resistance.
Authors:
Glynn, Judith R; Kremer, Kristin; Borgdorff, Martien W; Rodriguez, Mar Pujades; Soolingen, Dick van
Abstract:
Beijing/W genotype Mycobacterium tuberculosis is widespread, may be increasing, and may have a predilection for drug resistance. Individual-level data on >29,000 patients from 49 studies in 35 countries were combined to assess the Beijing genotype's prevalence worldwide, trends over time and with age, and associations with drug resistance. We found 4 patterns for Beijing/W genotype tuberculosis (TB): 1) endemic, not associated with drug resistance (high level in most of East Asia, lower level in parts of the United States); 2) epidemic, associated with drug resistance (high level in Cuba, the former Soviet Union, Vietnam, and South Africa, lower level in parts of Western Europe); 3) epidemic but drug sensitive (Malawi, Argentina); and 4) very low level or absent (parts of Europe, Africa). This study confirms that Beijing/W genotype TB is an emerging pathogen in several areas and a predominant endemic strain in others; it is frequently associated with drug resistance.
Citation:
Emerging Infect. Dis. 2006, 12(5):736-43
Issue Date:
1-May-2006
URI:
http://hdl.handle.net/10029/7598
PubMed ID:
16704829
Type:
Article
Language:
en
ISSN:
1080-6040
Appears in Collections:
Infectious Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorGlynn, Judith R-
dc.contributor.authorKremer, Kristin-
dc.contributor.authorBorgdorff, Martien W-
dc.contributor.authorRodriguez, Mar Pujades-
dc.contributor.authorSoolingen, Dick van-
dc.date.accessioned2007-01-17T15:49:54Z-
dc.date.available2007-01-17T15:49:54Z-
dc.date.issued2006-05-01-
dc.identifier.citationEmerging Infect. Dis. 2006, 12(5):736-43en
dc.identifier.issn1080-6040-
dc.identifier.pmid16704829-
dc.identifier.urihttp://hdl.handle.net/10029/7598-
dc.description.abstractBeijing/W genotype Mycobacterium tuberculosis is widespread, may be increasing, and may have a predilection for drug resistance. Individual-level data on >29,000 patients from 49 studies in 35 countries were combined to assess the Beijing genotype's prevalence worldwide, trends over time and with age, and associations with drug resistance. We found 4 patterns for Beijing/W genotype tuberculosis (TB): 1) endemic, not associated with drug resistance (high level in most of East Asia, lower level in parts of the United States); 2) epidemic, associated with drug resistance (high level in Cuba, the former Soviet Union, Vietnam, and South Africa, lower level in parts of Western Europe); 3) epidemic but drug sensitive (Malawi, Argentina); and 4) very low level or absent (parts of Europe, Africa). This study confirms that Beijing/W genotype TB is an emerging pathogen in several areas and a predominant endemic strain in others; it is frequently associated with drug resistance.en
dc.format.extent202632 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleBeijing/W genotype Mycobacterium tuberculosis and drug resistance.en
dc.typeArticleen
dc.format.digYES-

Related articles on PubMed

All Items in WARP are protected by copyright, with all rights reserved, unless otherwise indicated.