Depression and cardiovascular mortality: a role for n-3 fatty acids?

2.50
Hdl Handle:
http://hdl.handle.net/10029/8379
Title:
Depression and cardiovascular mortality: a role for n-3 fatty acids?
Authors:
Kamphuis, Marjolein H; Geerlings, Mirjam I; Tijhuis, Marja A R; Kalmijn, Sandra; Grobbee, Diederick E; Kromhout, Daan
Abstract:
BACKGROUND: Recent studies indicate that depression plays an important role in the occurrence of cardiovascular diseases (CVDs). The underlying mechanisms are not well understood. OBJECTIVE: We investigated whether dietary intake of the n-3 fatty acids (FAs) eicosapentaenic acid and docosahexaenoic acid could explain the relation between depressive symptoms and cardiovascular mortality. DESIGN: The Zutphen Elderly Study is a prospective cohort study conducted in the Netherlands. Depressive symptoms were measured in 1990 with the Zung Self-rating Depression Scale in 332 men aged 70-90 y and free from CVD and diabetes. Dietary factors were assessed with a cross-check dietary history method in 1990. Mortality data were collected between 1990 and 2000. Logistic and Cox regression analyses were performed, with adjustment for demographics and CVD risk factors. RESULTS: Compared with a low intake (x: 21 mg/d), a high intake (x: 407 mg/d) of n-3 FAs was associated with fewer depressive symptoms [odds ratio: 0.46; 95% CI: 0.22, 0.95; P for trend = 0.04] at baseline and no significant reduced risk of 10-y CVD mortality [hazard ratio (HR): 0.88; 95% CI: 0.51, 1.50]. The adjusted HR for an increase in depressive symptoms with 1 SD for CVD mortality was 1.28 (95% CI: 1.03, 1.57) and did not change after additional adjustment for the intake of n-3 FAs. CONCLUSION: An average intake of approximately 400 mg n-3 FA/d may reduce the risk of depression. Our results, however, do not support the hypothesis that the intake of n-3 FAs explains the relation between depression and CVD.
Citation:
Am. J. Clin. Nutr. 2006, 84(6):1513-7
Issue Date:
1-Dec-2006
URI:
http://hdl.handle.net/10029/8379
PubMed ID:
17158437
Type:
Article
Language:
en
ISSN:
0002-9165
Appears in Collections:
Nutrition and Drinking Water

Full metadata record

DC FieldValue Language
dc.contributor.authorKamphuis, Marjolein H-
dc.contributor.authorGeerlings, Mirjam I-
dc.contributor.authorTijhuis, Marja A R-
dc.contributor.authorKalmijn, Sandra-
dc.contributor.authorGrobbee, Diederick E-
dc.contributor.authorKromhout, Daan-
dc.date.accessioned2007-02-14T11:48:41Z-
dc.date.available2007-02-14T11:48:41Z-
dc.date.issued2006-12-01-
dc.identifier.citationAm. J. Clin. Nutr. 2006, 84(6):1513-7en
dc.identifier.issn0002-9165-
dc.identifier.pmid17158437-
dc.identifier.urihttp://hdl.handle.net/10029/8379-
dc.description.abstractBACKGROUND: Recent studies indicate that depression plays an important role in the occurrence of cardiovascular diseases (CVDs). The underlying mechanisms are not well understood. OBJECTIVE: We investigated whether dietary intake of the n-3 fatty acids (FAs) eicosapentaenic acid and docosahexaenoic acid could explain the relation between depressive symptoms and cardiovascular mortality. DESIGN: The Zutphen Elderly Study is a prospective cohort study conducted in the Netherlands. Depressive symptoms were measured in 1990 with the Zung Self-rating Depression Scale in 332 men aged 70-90 y and free from CVD and diabetes. Dietary factors were assessed with a cross-check dietary history method in 1990. Mortality data were collected between 1990 and 2000. Logistic and Cox regression analyses were performed, with adjustment for demographics and CVD risk factors. RESULTS: Compared with a low intake (x: 21 mg/d), a high intake (x: 407 mg/d) of n-3 FAs was associated with fewer depressive symptoms [odds ratio: 0.46; 95% CI: 0.22, 0.95; P for trend = 0.04] at baseline and no significant reduced risk of 10-y CVD mortality [hazard ratio (HR): 0.88; 95% CI: 0.51, 1.50]. The adjusted HR for an increase in depressive symptoms with 1 SD for CVD mortality was 1.28 (95% CI: 1.03, 1.57) and did not change after additional adjustment for the intake of n-3 FAs. CONCLUSION: An average intake of approximately 400 mg n-3 FA/d may reduce the risk of depression. Our results, however, do not support the hypothesis that the intake of n-3 FAs explains the relation between depression and CVD.en
dc.format.extent104417 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.titleDepression and cardiovascular mortality: a role for n-3 fatty acids?en
dc.typeArticleen
dc.format.digYES-

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