"Relatieve orale biobeschikbaarheid van contaminanten in bodem": Overzicht van werkzaamheden 1996-2001 met koppeling aan beleidsvragen

2.50
Hdl Handle:
http://hdl.handle.net/10029/9664
Title:
"Relatieve orale biobeschikbaarheid van contaminanten in bodem": Overzicht van werkzaamheden 1996-2001 met koppeling aan beleidsvragen
Authors:
Rompelberg CJM; Zwart LL de
Other Titles:
"Relative oral bioavailability of contaminants from soil". Overview of activities from 1996 to 2001 coupled to policy issues
Abstract:
In current risk assessment of soil contaminants, oral bioavailability of contaminants from soil in humans (Fsoil) is considered to be equal to the bioavailability of contaminants from the matrix used in the toxicological studies (Fmatrix tox. study) underlying the Maximal Permissible Risk level. There are indications that this consideration is not valid. Research on relative bioavailability factors (=Fsoil/ Fmatrix tox. study) of soil contaminants is needed for more insight into relative bioavailiability factors and to decide whether risk assessment can be improved by experimental determination of these factors. The (still ongoing) research on relative bioavailability factors of soil contaminants at the Laboratory of Exposure Assessment and Environmental Epidemiology of the National Institute for Public Health and the Environment in the 1996-2001 period has been summarised in the current report. To date, an in vitro digestion model and a (preliminary) mathematical model have been developed and tested to explore the relative bioavailability of contaminants in soil. It can be concluded that both models are promising tools to study relative bioavailability factors. The current report will be used to decide how research has to be continued.
Affiliation:
LBM
Publisher:
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Issue Date:
25-Feb-2002
URI:
http://hdl.handle.net/10029/9664
Additional Links:
http://www.rivm.nl/bibliotheek/rapporten/711701027.html
Language:
nl
Series/Report no.:
RIVM Rapport 711701027
Appears in Collections:
RIVM reports - old archive

Full metadata record

DC FieldValue Language
dc.contributor.authorRompelberg CJMen_US
dc.contributor.authorZwart LL deen_US
dc.date.accessioned2007-02-27T12:57:52Z-
dc.date.available2007-02-27T12:57:52Z-
dc.date.issued2002-02-25en_US
dc.identifier711701027en_US
dc.identifier.urihttp://hdl.handle.net/10029/9664-
dc.description.abstractIn current risk assessment of soil contaminants, oral bioavailability of contaminants from soil in humans (Fsoil) is considered to be equal to the bioavailability of contaminants from the matrix used in the toxicological studies (Fmatrix tox. study) underlying the Maximal Permissible Risk level. There are indications that this consideration is not valid. Research on relative bioavailability factors (=Fsoil/ Fmatrix tox. study) of soil contaminants is needed for more insight into relative bioavailiability factors and to decide whether risk assessment can be improved by experimental determination of these factors. The (still ongoing) research on relative bioavailability factors of soil contaminants at the Laboratory of Exposure Assessment and Environmental Epidemiology of the National Institute for Public Health and the Environment in the 1996-2001 period has been summarised in the current report. To date, an in vitro digestion model and a (preliminary) mathematical model have been developed and tested to explore the relative bioavailability of contaminants in soil. It can be concluded that both models are promising tools to study relative bioavailability factors. The current report will be used to decide how research has to be continued.en
dc.format.extent357000 bytesen_US
dc.format.extent365267 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isonlen_US
dc.publisherRijksinstituut voor Volksgezondheid en Milieu RIVMen_US
dc.relation.ispartofseriesRIVM Rapport 711701027en_US
dc.relation.urlhttp://www.rivm.nl/bibliotheek/rapporten/711701027.htmlen_US
dc.subject.otherbioaccessibilityen
dc.subject.otherrelatieve biobeschikbaarheidnl
dc.subject.otherrisicoschatting bodemnl
dc.subject.otherin vitro digestiemodelnl
dc.title"Relatieve orale biobeschikbaarheid van contaminanten in bodem": Overzicht van werkzaamheden 1996-2001 met koppeling aan beleidsvragenen_US
dc.title.alternative"Relative oral bioavailability of contaminants from soil". Overview of activities from 1996 to 2001 coupled to policy issuesen_US
dc.contributor.departmentLBMen_US
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