RIVM Publications Repository
Each year the Dutch National Institute for Public Health and the Environment (RIVM) produces numerous reports and publications on all aspects of public health, nutrition and food, health care, disaster management, nature and the environment.
In addition, RIVM employees publish scientific articles in national and international journals.
Elk jaar brengt het Rijksinstituut voor Volksgezondheid en Milieu (RIVM) talloze rapporten en adviezen uit over volksgezondheid en gezondheidszorg, voeding, natuur en milieu en rampenbestrijding.
Daarnaast publiceren RIVM-medewerkers wetenschappelijke artikelen in (inter-)nationale tijdschriften.
We are constantly working to improve the Repository. Please contact our administrator if you have any further questions or remarks.
Recent Submissions
Item Bevolkingsblootstelling aan luchtvervuiling 2022 en 2023(Rijksinstituut voor Volksgezondheid en Milieu RIVM, 2025-07-17)Publication Chain length and chlorine position affect biotransformation of chlorinated paraffins in an in vitro hepatic model.(2025-05-26)Chlorinated paraffins (CPs) are emerging environmental contaminants with limited biotransformation data because of the complexity of CP technical mixtures and the lack of single congener standards. In this study, novel single CP congeners, with similar chlorine patterns to those found in technical mixtures, were incubated for 60 min with rat hepatic subcellular fractions to evaluate their relative biotransformation extent and identify their potential metabolites. Results demonstrated that these CP congeners were metabolized by phenobarbital and 5,6-benzoflavone-induced rat liver S9, following 1st-order kinetics. The 1st-order rate constants were logarithmically inversely related to the chain lengths at a given number of chlorine atoms. In turn, the chlorine positions affected the biotransformation pathways, resulting in the formation of different metabolites. Metabolites identified by high-resolution mass spectrometric analysis included (multi-)hydroxylated, carbonyl, carboxylic, and chain-shortened products. Hydrolytic and oxidative dechlorination, stepwise hydroxylation/oxidation, and C-C bond cleavage were identified as potential biotransformation pathways. A notable transformation of initial hydroxylated metabolites further into aldehydes and carboxylic acids (ω-oxidation) was emphasized. The study's results fill the knowledge gap in CP biotransformation and provide structural information on potentially bioactive CP metabolites for future synthesis and toxicity studies.Item Verkenning proxies voor nitraat(Rijksinstituut voor Volksgezondheid en Milieu RIVM, 2025-07-11)Publication Navigating the black box of fair national emissions targets(2025-06-16)Current national emissions targets fall short of the Paris Agreement goals, prompting the need for equitable ways to close this gap. Fair emissions allowances rely on efort-sharing formulas based on fairness principles, yielding diverse outcomes. These variations, shaped by normative decisions, complicate policymaking and legal assessments of climate targets. Here we provide up-to-date numbers, comprehensively accounting for three dimensions — physical and social uncertainties, global strategies and equity — and the relative impact of them on each country’s emissions allowance. In the short run, normative considerations substantially impact fair emissions allowances — directing current discussions to this debate — while global discussions on temperature targets and non-CO2 emissions take over in the long run. We identify many countries with insufcient nationally determined contributions in light of fairness and discuss implications for increased domestic mitigation and fnancing emissions reductions abroad — yielding a total international fnance fux of $US0.5–7.4 trillion in 2030.
Communities in RIVM Publications Repository
Select a community to browse its collections.