Whole-Genome Next-Generation Sequencing to Study Within-Host Evolution of Norovirus (NoV) Among Immunocompromised Patients With Chronic NoV Infection.
van Beek, Janko de Graaf, Miranda Smits, Saskia Schapendonk, Claudia M E Verjans, Georges M G M Vennema, Harry van der Eijk, Annemiek A Phan, My V T Cotten, Matthew Koopmans, Marion
van Beek, Janko
de Graaf, Miranda
Smits, Saskia
Schapendonk, Claudia M E
Verjans, Georges M G M
Vennema, Harry
van der Eijk, Annemiek A
Phan, My V T
Cotten, Matthew
Koopmans, Marion
Series / Report no.
Open Access
Type
Article
Language
en
Date
2017-12-19
Research Projects
Organizational Units
Journal Issue
Title
Whole-Genome Next-Generation Sequencing to Study Within-Host Evolution of Norovirus (NoV) Among Immunocompromised Patients With Chronic NoV Infection.
Translated Title
Published in
J Infect Dis 2017; 216(12):1513-24
Abstract
The genus Norovirus comprises large genetic diversity, and new GII.4 variants emerge every 2-3 years. It is unknown in which host these new variants originate. Here we study whether prolonged shedders within the immunocompromised population could be a reservoir for newly emerging strains.