Onderzoek naar de mutagene werking van mogelijke intermediairen van de stofwisseling van 5-fenyl-2-pyridineamine op microorganismen
Voogd CE Stel JJ van der Stavenuiter JFC Bruchem MC van
Voogd CE
Stel JJ van der
Stavenuiter JFC
Bruchem MC van
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Series / Report no.
Open Access
Type
Report
Language
nl
Date of publication
1990-04-30
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Onderzoek naar de mutagene werking van mogelijke
intermediairen van de stofwisseling van 5-fenyl-2-pyridineamine op
microorganismen
Translated Title
Investigation of the mutagenic activity of some
possible intermediary compounds of the 5-phenyl-2-pyridineamine metabolism
on micro-organisms
Published in
Abstract
Abstract niet beschikbaar
Six compounds were investigated on mutagenicity in order to obtain information whether they would be responsible for the mutagenicity of the amino acid pyrolysate 5-phenyl-2-pyridineamine. Of these compounds 2-acetylamino-5-phenylpyridine was not mutagenic in the Ames-test. With 2-nitro-5-phenylpyridine, 2-acetylhydroxylamino-5-phenylpyridine and N2- acetoxy-5-phenyl-2-pyridineamine a mutagenic activity with one or more of the Salmonella typhimurium strains of the Ames-test was found at quantities of 50-500 mug per selection plate. Furthermore, no relevant differences in numbers of revertants were found with the strains TA98, TA98 NR en TA98/1,8 DNP with 2-nitro-5-phenylpyridine. The remaining compounds were not investigated with TA98 NR and TA98 DNP. None of the investigated compounds can, therefore, be considered as the ultimate mutagen intermediate compound on the basis of data obtained in the present investigations.
Six compounds were investigated on mutagenicity in order to obtain information whether they would be responsible for the mutagenicity of the amino acid pyrolysate 5-phenyl-2-pyridineamine. Of these compounds 2-acetylamino-5-phenylpyridine was not mutagenic in the Ames-test. With 2-nitro-5-phenylpyridine, 2-acetylhydroxylamino-5-phenylpyridine and N2- acetoxy-5-phenyl-2-pyridineamine a mutagenic activity with one or more of the Salmonella typhimurium strains of the Ames-test was found at quantities of 50-500 mug per selection plate. Furthermore, no relevant differences in numbers of revertants were found with the strains TA98, TA98 NR en TA98/1,8 DNP with 2-nitro-5-phenylpyridine. The remaining compounds were not investigated with TA98 NR and TA98 DNP. None of the investigated compounds can, therefore, be considered as the ultimate mutagen intermediate compound on the basis of data obtained in the present investigations.
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