Biodistribution of cerium dioxide and titanium dioxide nanomaterials in rats after single and repeated inhalation exposures
Gosens, Ilse Minnema, Jordi Boere, A John F Duistermaat, Evert Fokkens, Paul Vidmar, Janja Löschner, Katrin Bokkers, Bas Costa, Anna L Peters, Ruud JB
Gosens, Ilse
Minnema, Jordi
Boere, A John F
Duistermaat, Evert
Fokkens, Paul
Vidmar, Janja
Löschner, Katrin
Bokkers, Bas
Costa, Anna L
Peters, Ruud JB
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2024-08-14
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Biodistribution of cerium dioxide and titanium dioxide nanomaterials in rats after single and repeated inhalation exposures
Translated Title
Published in
Part Fibre Toxicol 2024; 21(1):33
Abstract
Rats were exposed to cerium dioxide (CeO2, 28.4 ± 10.4 nm) and titanium dioxide (TiO2, 21.6 ± 1.5 nm) ENMs in a single nose-only exposure to 20 mg/m3 or a repeated exposure of 2 × 5 days to 5 mg/m3. Different dose levels were obtained by varying the exposure time for 30 min, 2 or 6 h per day. The content of cerium or titanium in three compartments of the lung (tissue, epithelial lining fluid and freely moving cells), mediastinal lymph nodes, liver, spleen, kidney, blood and excreta was measured by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) at various time points post-exposure. As biodistribution is best studied at sub-toxic dose levels, lactate dehydrogenase (LDH), total protein, total cell numbers and differential cell counts were determined in bronchoalveolar lavage fluid (BALF).