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Series / Report no.
Open Access
Type
Report
Language
en
Date
1992-01-31
Research Projects
Organizational Units
Journal Issue
Title
Viruses and cancer
Translated Title
Virussen en kanker
Published in
Abstract
The aim of this report is to review the relationship between viruses and the development of human cancer. It is currently known at least four viruses are directly implicated in the aetiology of human cancers and are involved in the induction of 15 to 20% of the worldwide tumor burden. Infection with these viruses seems to be an essential, but not sufficient, step in the multistage proces of carcinogenesis. Other changes, induced for instance by chemical carcinogens or radiation, are also required to change the virus infected cell into a tumor cell. The four most important human tumor viruses are: human T cell leukemia viruses (HTLV); Epstein-Barr virus (EBV); hepatitis B virus (HBV) and human papillomavirus (HPV). Because of HPV is probably involved in the development of over 10% of all human tumors and hence is the most important biological agent in relation to cancer, it is discussed more extensively in this report.<br>
Description
Publisher
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Sponsors
RIVM