The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation.
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Type
Article
Language
en
Date
2023-01-27
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Title
The contribution of the alternative pathway in complement activation on cell surfaces depends on the strength of classical pathway initiation.
Translated Title
Published in
Clin Transl Immunol 2023;12(1):e1436
Abstract
We evaluated the contribution of the AP to complement responses initiated through the CP on human RBCs by serum of AIHA patients and recombinant antibodies. Moreover, we studied complement activation on Neisseria meningitidis and Escherichia coli. The effect of the AP was examined using either AP-depleted sera or antibodies against factor B and factor D.