Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study.
Simoes, Margarida Pires; Hodcroft, Emma B; Simmonds, Peter; Albert, Jan; Alidjinou, Enagnon K; Ambert-Balay, Katia; Andrés, Cristina; Antón, Andrés; Auvray, Christelle; Bailly, Jean-Luc; Baldanti, Fausto; Bastings, Capser; Beard, Stuart; Berengua, Carla; Berginc, Natasa; Bloemen, Mandy; Blomqvist, Soile; Bosma, Froukje; Böttcher, Sindy; Bubba, Laura; Buderus, Stafan; Cabrerizo, Maria; Calvo, Cristina; Celma, Cristina; Ceriotti, Ferruccio; Clark, Gemma; Costa, Inës; Coste-Burel, Marianne; Couderé, Karen; Cremer, Jeroen; Del Cuerpo Casas, Margarita; Daehne, Theo; de Beer, Jessica; de Ceano-Vivas, Maria; De Gascun, Cillian; de Rougemont, Alexis; Dean, Jonathan; Dembinski, Jennifer L; Diedrich, Sabine; Diez-Domingo, Javier; Dillner, Lena; Dorenberg, Dagny H; Ducancelle, Alexandra; Dudman, Susanne; Dyrdak, Robert; Eis-Huebinger, Anna-Maria; Falces-Romero, Iker; Farkas, Agnes; Feeney, Susan; Fernandez-Garcia, Maria D; Flipse, Jacky; Franck, Kristina T; Galli, Cristina; Garrigue, Isabelle; Geeraedts, Felix; Georgieva, Irina; Giardina, Federica; Guiomar, Raquel; Hauzenberger, Elenor; Heikens, Esther; Henquell, Cécille; Hober, Didier; Hönemann, Mario; Howson-Wells, Hannah; Hruškar, Željka; Ikonen, Niina; Imbert, Berthemarie; Jansz, Arjan R; Jeannoël, Marion; Jiřincová, Helena; Josset, Laurence; Keeren, Kathrin; Kramer-Lindhout, Naomie; Krokstad, Sidsel; Lazrek, Mouna; Le Guillou-Guillemette, Hélène; Lefeuvre, Caroline; Lind, Andreas; Lunar, Maja M; Maier, Melanie; Marque-Juillet, Stéphanie; McClure, C Patrick; McKenna, James; Meijer, Adam; Menasalvas Ruiz, Ana; Mengual-Chuliá, Beatriz; Midgley, Sofie; Mirand, Audrey; Molenkamp, Richard; Montes, Milagrosa; Moreno-Docón, Antonio; Morley, Ursula; Murk, Jean-Luc; Navascués-Ortega, Ana; Nijhuis, Roel; Nikolaeva-Glomb, Lubomira; Nordbø, Svein A; Numanovic, Sanela; Oggioni, Massimo; Oñate Vergara, Eider; Pacaud, Jordi; Pacreau, Marie L; Panning, Marcus; Pariani, Elena; Pekova, Lili; Pellegrinelli, Laura; Petrovec, Miroslav; Pietsch, Corinna; Pilorge, Léa; Piñeiro, Luis; Piralla, Antonio; Poljak, Mario; Prochazka, Birgit; Rabella, Nuria; Rahamat-Langendoen, Janette C; Rainetova, Petra; Reynders, Marijke; Riezebos-Brilman, Annelies; Roorda, Lieuwe; Savolainen-Kopra, Carita; Schuffenecker, Isabelle; Smeets, Leo C; Stoyanova, Asya; Stefic, Karl; Swanink, Caroline; Tabain, Irena; Tjhie, Jeroen; Thouault, Luc; Tumiotto, Camille; Uceda Renteria, Sara; Uršič, Tina; Vallet, Sophie; Van Ranst, Marc; Van Wunnik, Peter; Verweij, Jaco J; Vila, Jorgina; Wintermans, Bas; Wollants, Elke; Wolthers, Katja C; Xavier López-Labrador, F; Fischer, Thea Kolsen; Harvala, Heli; Benschop, Kimberley S M
Series / Report no.
Open Access
Type
Article
Language
en
Date
2024-10-16
Research Projects
Organizational Units
Journal Issue
Title
Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study.
Translated Title
Published in
J Infect Dis 2024; 230(4):e917-e928
Abstract
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.