Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents.
Lubczyńska, Małgorzata J Muetzel, Ryan L El Marroun, Hanan Basagaña, Xavier Strak, Maciej Denault, William Jaddoe, Vincent W V Hillegers, Manon Vernooij, Meike W Hoek, Gerard
Lubczyńska, Małgorzata J
Muetzel, Ryan L
El Marroun, Hanan
Basagaña, Xavier
Strak, Maciej
Denault, William
Jaddoe, Vincent W V
Hillegers, Manon
Vernooij, Meike W
Hoek, Gerard
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2020-02-01
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Exposure to Air Pollution during Pregnancy and Childhood, and White Matter Microstructure in Preadolescents.
Translated Title
Published in
Environ Health Perspect 2020; 128(2):27005
Abstract
We used data of 2,954 children from the Generation R Study, a population-based birth cohort from Rotterdam, Netherlands (2002-2006). Concentrations of 17 air pollutants including nitrogen oxides (
NO
X
), particulate matter (PM), and components of PM were estimated at participants' homes during pregnancy and childhood using land-use regression models. Diffusion tensor images were obtained at child's 9-12 years of age, and fractional anisotropy (FA) and mean diffusivity (MD) were computed. We performed linear regressions adjusting for socioeconomic and lifestyle characteristics. Single-pollutant analyses were followed by multipollutant analyses using the Deletion/Substitution/Addition (DSA) algorithm.