Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells.
Skuland, Tonje Grytting, Vegard Sæter Låg, Marit Jørgensen, Rikke Bræmming Snilsberg, Brynhild Leseman, Daan L A C Kubátová, Alena Emond, Jessica Cassee, Flemming R Holme, Jørn A
Skuland, Tonje
Grytting, Vegard Sæter
Låg, Marit
Jørgensen, Rikke Bræmming
Snilsberg, Brynhild
Leseman, Daan L A C
Kubátová, Alena
Emond, Jessica
Cassee, Flemming R
Holme, Jørn A
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Series / Report no.
Open Access
Type
Article
Other
Other
Language
en
Date of publication
2022-07-04
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells.
Translated Title
Published in
Part Fibre Toxicol 2022;19(1):45
Abstract
The pro-inflammatory potency of the PM samples varied between road tunnels and size fractions, but showed more marked responses than for the stone materials used in asphalt of the respective tunnels. In particular, fine samples showed significant increases as low as 25 µg/mL (2.6 µg/cm2) and were more potent than coarse samples, while ultrafine samples showed more variable responses between tunnels, sampling conditions and endpoints. The most marked responses were observed for fine PM sampled during humid road surface conditions. Linear correlation analysis showed that particle-induced cytokine responses were correlated to OC levels, while no correlations were observed for other PM characteristics.