Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation.
van Erp, Elisabeth A Lakerveld, Anke J de Graaf, Erik Larsen, Mads D Schepp, Rutger M Hipgrave Ederveen, Agnes L Ahout, Inge Ml de Haan, Cornelis Am Wuhrer, Manfred Luytjes, Willem
van Erp, Elisabeth A
Lakerveld, Anke J
de Graaf, Erik
Larsen, Mads D
Schepp, Rutger M
Hipgrave Ederveen, Agnes L
Ahout, Inge Ml
de Haan, Cornelis Am
Wuhrer, Manfred
Luytjes, Willem
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Open Access
Type
Article
Language
en
Date
2020-01-01
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Title
Natural killer cell activation by respiratory syncytial virus-specific antibodies is decreased in infants with severe respiratory infections and correlates with Fc-glycosylation.
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Published in
Clin Transl Immunology 2020; 9(2):e1112
Abstract
We found that RSV-specific maternal antibodies activate NK cells in vitro. While concentrations of RSV-specific antibodies did not differ between cases and controls, antibodies from infants hospitalised for severe respiratory infections (RSV and/or other) induced significantly less NK cell interferon-γ production than those from uninfected controls. Furthermore, NK cell activation correlated with Fc-fucosylation of RSV-specific antibodies, but their glycosylation status did not significantly differ between cases and controls.