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Preclinical and clinical safety studies on DNA vaccines.
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Series / Report no.
Open Access
Type
Article
Language
en
Date
2007-01-03T12:37:38Z
Research Projects
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Journal Issue
Title
Preclinical and clinical safety studies on DNA vaccines.
Translated Title
Published in
Abstract
DNA vaccines are based on the transfer of genetic material, encoding an antigen, to the cells of the vaccine recipient. Despite high expectations of DNA vaccines as a result of promising preclinical data their clinical utility remains unproven. However, much data is gathered in preclinical and clinical studies about the safety of DNA vaccines. Here we review current knowledge about the safety of DNA vaccines. Safety concerns of DNA vaccines relate to genetic, immunologic, toxic, and environmental effects. In this review we provide an overview of findings related to the safety of DNA vaccines, obtained so far. We conclude that the potential risks of DNA vaccines are minimal. However, their safety issues may differ case-by-case, and they should be treated accordingly.