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Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia.
Sengstake, Sarah Bergval, Indra L Schuitema, Anja R de Beer, Jessica L Phelan, Jody de Zwaan, Rina Clark, Taane G van Soolingen, Dick Anthony, Richard M
Sengstake, Sarah
Bergval, Indra L
Schuitema, Anja R
de Beer, Jessica L
Phelan, Jody
de Zwaan, Rina
Clark, Taane G
van Soolingen, Dick
Anthony, Richard M
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2017-07-12
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia.
Translated Title
Published in
BMC Infect Dis 2017, 17(1):491
Abstract
The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies. A new regimen to treat MDR-TB that includes pyrazinamide (PZA) is currently being evaluated and PZA resistance status will largely influence the success of current and future treatment strategies. PZA susceptibility testing was not routinely performed at the National Reference Laboratory (NRL) in Tbilisi between 2010 and September 2015. We here provide a first insight into the prevalence of PZA resistant TB in this region.