Discovery of trehalose phospholipids reveals functional convergence with mycobacteria.
Reinink, Peter; Buter, Jeffrey; Mishra, Vivek K; Ishikawa, Eri; Cheng, Tan-Yun; Willemsen, Peter T J; Porwollik, Steffen; Brennan, Patrick J; Heinz, Eva; Mayfield, Jacob A; Dougan, Gordon; van Els, Cécile A; Cerundolo, Vincenzo; Napolitani, Giorgio; Yamasaki, Sho; Minnaard, Adriaan J; McClelland, Michael; Moody, D Branch; Van Rhijn, Ildiko
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Open Access
Type
Article
Language
en
Date
2019-02-25
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Title
Discovery of trehalose phospholipids reveals functional convergence with mycobacteria.
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Published in
J Exp Med 2019; 216(4):757-71
Abstract
species are among the world's most prevalent pathogens. Because the cell wall interfaces with the host, we designed a lipidomics approach to reveal pathogen-specific cell wall compounds. Among the molecules differentially expressed between