Increased colon cancer risk after severe Salmonella infection.
Mughini-Gras, Lapo Schaapveld, Michael Kramers, Jolanda Mooij, Sofie Neefjes-Borst, E Andra Pelt, Wilfrid van Neefjes, Jacques
Mughini-Gras, Lapo
Schaapveld, Michael
Kramers, Jolanda
Mooij, Sofie
Neefjes-Borst, E Andra
Pelt, Wilfrid van
Neefjes, Jacques
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Title
Increased colon cancer risk after severe Salmonella infection.
Translated Title
Published in
Plos One 2018; 13(1):e0189721
Abstract
Colon cancer constitutes one of the most frequent malignancies. Previous studies showed that Salmonella manipulates host cell signaling pathways and that Salmonella Typhimurium infection facilitates colon cancer development in genetically predisposed mice. This epidemiological study examined whether severe Salmonella infection, usually acquired from contaminated food, is associated with increased colon cancer risk in humans.