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Triglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile.
Ibi, Dorina Blauw, Lisanne L Noordam, Raymond Dollé, Martijn E T Jukema, J Wouter Rosendaal, Frits R Christodoulides, Constantinos Neville, Matt J Koivula, Robert Rensen, Patrick C N
Ibi, Dorina
Blauw, Lisanne L
Noordam, Raymond
Dollé, Martijn E T
Jukema, J Wouter
Rosendaal, Frits R
Christodoulides, Constantinos
Neville, Matt J
Koivula, Robert
Rensen, Patrick C N
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Series / Report no.
Open Access
Type
Article
Language
en
Date
2021-05-09
Research Projects
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Journal Issue
Title
Triglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile.
Translated Title
Published in
Atherosclerosis 2021; 328:144-52
Abstract
Compared to the individual groups with genetically-influenced lower TG or lower LDL-C only, the group with combined genetically-influenced lower TG and LDL-C showed an overall independent and additive pattern of changes in metabolomic measures. Over 100 measures were different (p < 1.35 × 10-3) compared to the reference, with effect sizes and directionality being similar in NEO and OBB. Most notably, levels of all very-low density lipoprotein (VLDL) and LDL sub-particles were lower.