Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
Buelow, Elena; Bello Gonzalez, Teresita dJ; Fuentes, Susana; de Steenhuijsen Piters, Wouter AA; Lahti, Leo; Bayjanov, Jumamurat R; Majoor, Eline AM; Braat, Johanna C; van Mourik, Maaike S M; Oostdijk, Evelien AN; Willems, Rob JL; Bonten, Marc J M; van Passel, Mark WJ; Smidt, Hauke; van Schaik, Willem
Citations
Altmetric:
Series / Report no.
Open Access
Type
Article
Language
en
Date
2017-08-14
Research Projects
Organizational Units
Journal Issue
Title
Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
Translated Title
Published in
Microbiome 2017, 5(1):188
Abstract
The gut microbiota is a reservoir of opportunistic pathogens that can cause life-threatening infections in critically ill patients during their stay in an intensive care unit (ICU). To suppress gut colonization with opportunistic pathogens, a prophylactic antibiotic regimen, termed "selective decontamination of the digestive tract" (SDD), is used in some countries where it improves clinical outcome in ICU patients. Yet, the impact of ICU hospitalization and SDD on the gut microbiota remains largely unknown. Here, we characterize the composition of the gut microbiota and its antimicrobial resistance genes ("the resistome") of ICU patients during SDD and of healthy subjects.