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An alternative approach identified optimal risk thresholds for treatment indication: an illustration in coronary heart disease.
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Title
An alternative approach identified optimal risk thresholds for treatment indication: an illustration in coronary heart disease.
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Published in
J Clin Epidemiol 2018; 94:122-31
Abstract
Treatment thresholds based on risk predictions can be optimized by considering various health (economic) outcomes and performing marginal analyses, but this is rarely performed. We demonstrate a general approach to identify treatment thresholds optimizing individual health (economic) outcomes, illustrated for statin treatment based on 10-year coronary heart disease (CHD) risk predicted by the Framingham risk score.