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An alternative approach identified optimal risk thresholds for treatment indication: an illustration in coronary heart disease.
van Giessen, Anoukh de Wit, G Ardine Moons, Karel G M Dorresteijn, Jannick A N Koffijberg, Hendrik
van Giessen, Anoukh
de Wit, G Ardine
Moons, Karel G M
Dorresteijn, Jannick A N
Koffijberg, Hendrik
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2018-02
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
An alternative approach identified optimal risk thresholds for treatment indication: an illustration in coronary heart disease.
Translated Title
Published in
J Clin Epidemiol 2018; 94:122-31
Abstract
Treatment thresholds based on risk predictions can be optimized by considering various health (economic) outcomes and performing marginal analyses, but this is rarely performed. We demonstrate a general approach to identify treatment thresholds optimizing individual health (economic) outcomes, illustrated for statin treatment based on 10-year coronary heart disease (CHD) risk predicted by the Framingham risk score.