WHO Coordination Interlaboratory Calibration Study on the Analysis of Dioxins and PCB's in Human Milk and Blood
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Series / Report no.
Open Access
Type
Report
Language
en
Date
1991-08-31
Research Projects
Organizational Units
Journal Issue
Title
WHO Coordination Interlaboratory Calibration Study
on the Analysis of Dioxins and PCB's in Human Milk and
Blood
Translated Title
WHO Gecoordineerd interlaboratorium onderzoek over
de analyse van dioxines and PCB's in moedermelk en
bloed
Published in
Abstract
Abstract niet beschikbaar
This report describes the results of a WHO-coordinated interlaboratory comparison study on the analysis of dioxins and PCBs in mother's milk and human blood. The study is biannually organised by the WHO, Regional Office for Europe (Copenhagen) and is aiming at the identification of laboratories capable of the analysis of dioxins and related compounds at a good, internationally accepted standard. In the present study, nineteen laboratories from Europe and North- America have participated for dioxins in mother's milk, sixteen for dioxins in blood and ten and sic for the analysis of PCBs in mother's milk and human blood, respectively. The study consisted of the analysis of three different pools of milk and blood, two of which contained added PCDD/Fs. One of the pools was sent after the results of two previous pools have been reported (test for reproducability). Results were evaluated on the basis of statistical analysis in terms of repeatability, reproducibility and accuracy. In general, coefficients of varation (CV) were better for analysis in mother's milk than for the lower levels in blood. Limits for the qualification of methods were average coefficients of variation of < 20% for analysis of PCBs in milk and blood, <30% for dioxins in milk and <40% for dioxins in blood. All our four methods have been qualified. In the final ranking of laboratories, RIVM-LOC methods scored first positions for PCBs and dioxins in milk and for PCBs in blood and a third position for the analysis of dioxins in blood. The average CVs were 12.4, 3.3, 8.7 and 11,3% for analysis for PCBs and dioxins in milk and blood, respectively.
This report describes the results of a WHO-coordinated interlaboratory comparison study on the analysis of dioxins and PCBs in mother's milk and human blood. The study is biannually organised by the WHO, Regional Office for Europe (Copenhagen) and is aiming at the identification of laboratories capable of the analysis of dioxins and related compounds at a good, internationally accepted standard. In the present study, nineteen laboratories from Europe and North- America have participated for dioxins in mother's milk, sixteen for dioxins in blood and ten and sic for the analysis of PCBs in mother's milk and human blood, respectively. The study consisted of the analysis of three different pools of milk and blood, two of which contained added PCDD/Fs. One of the pools was sent after the results of two previous pools have been reported (test for reproducability). Results were evaluated on the basis of statistical analysis in terms of repeatability, reproducibility and accuracy. In general, coefficients of varation (CV) were better for analysis in mother's milk than for the lower levels in blood. Limits for the qualification of methods were average coefficients of variation of < 20% for analysis of PCBs in milk and blood, <30% for dioxins in milk and <40% for dioxins in blood. All our four methods have been qualified. In the final ranking of laboratories, RIVM-LOC methods scored first positions for PCBs and dioxins in milk and for PCBs in blood and a third position for the analysis of dioxins in blood. The average CVs were 12.4, 3.3, 8.7 and 11,3% for analysis for PCBs and dioxins in milk and blood, respectively.
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HIMH
HIGB
HIGB