Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination.
van der Lee, Saskia Kemmeren, Jeanet M de Rond, Lia G H Öztürk, Kemal Westerhof, Anneke de Melker, Hester E Sanders, Elisabeth A M Berbers, Guy A M van der Maas, Nicoline A T Rümke, Hans C
van der Lee, Saskia
Kemmeren, Jeanet M
de Rond, Lia G H
Öztürk, Kemal
Westerhof, Anneke
de Melker, Hester E
Sanders, Elisabeth A M
Berbers, Guy A M
van der Maas, Nicoline A T
Rümke, Hans C
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Title
Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination.
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Published in
Pediatr Infect Dis J 2017; 36(9):e223-9
Abstract
In the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination.