DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels: a systematic review and replication in a case-control sample of the Lifelines study.
Walaszczyk, Eliza Luijten, Mirjam Spijkerman, Annemieke M W Bonder, Marc J Lutgers, Helen L Snieder, Harold Wolffenbuttel, Bruce H R van Vliet-Ostaptchouk, Jana V
Walaszczyk, Eliza
Luijten, Mirjam
Spijkerman, Annemieke M W
Bonder, Marc J
Lutgers, Helen L
Snieder, Harold
Wolffenbuttel, Bruce H R
van Vliet-Ostaptchouk, Jana V
Citations
Altmetric:
Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2018-02
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels: a systematic review and replication in a case-control sample of the Lifelines study.
Translated Title
Published in
Diabetologia 2018; 61(2):354-68
Abstract
Epigenetic mechanisms may play an important role in the aetiology of type 2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels. Here we present a systematic review of these studies and attempt to replicate the CpG sites (CpGs) with the most significant associations from these EWASs in a case-control sample of the Lifelines study.