Pilot onderzoek naar effecten van verschillende doseringen histamine toegediend via vismonsters aan gezonde vrijwilligers
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Series / Report no.
Open Access
Type
Report
Language
nl
Date
1991-03-31
Research Projects
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Journal Issue
Title
Pilot onderzoek naar effecten van verschillende
doseringen histamine toegediend via vismonsters aan gezonde
vrijwilligers
Translated Title
Pilot experiment to investigate the effects of
several doses histamine administrated in fish samples to healthy
volunteers
Published in
Abstract
Abstract niet beschikbaar
The effects of histamine administrated in fish samples to 8 healthy volunteers (4 females and 4 males) have been studied. The fish samples contained 0, 45 or 90 mg histamine which had been metabolized by photobacteria in fish out of histidine, or 90 mg histamine added to fresh fish. The volunteers had the samples for breakfast in random order, with intervals of one week. Attention was paid to clinical symptoms. The pH of the stomach contents, the histamine concentration in plasma and the histamine metabolites in urine were also recorded.
The effects of histamine administrated in fish samples to 8 healthy volunteers (4 females and 4 males) have been studied. The fish samples contained 0, 45 or 90 mg histamine which had been metabolized by photobacteria in fish out of histidine, or 90 mg histamine added to fresh fish. The volunteers had the samples for breakfast in random order, with intervals of one week. Attention was paid to clinical symptoms. The pH of the stomach contents, the histamine concentration in plasma and the histamine metabolites in urine were also recorded.
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