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Variation in loss of immunity shapes influenza epidemics and the impact of vaccination.
Woolthuis, Rutger G Wallinga, Jacco van Boven, Michiel
Woolthuis, Rutger G
Wallinga, Jacco
van Boven, Michiel
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Open Access
Type
Article
Language
en
Date of publication
2017-09-19
Year of publication
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s12879-017-2716-y.pdf
Adobe PDF, 1.25 MB
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Title
Variation in loss of immunity shapes influenza epidemics and the impact of vaccination.
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Published in
BMC Infect Dis 2017, 17(1):632
Abstract
Protective antibody immunity against the influenza A virus wanes in 2-7 years due to antigenic drift of the virus' surface proteins. The duration of immune protection is highly variable because antigenic evolution of the virus is irregular. Currently, the variable nature of the duration of immunity has had little attention in analyses of the impact of vaccination, including cost-effectiveness studies.