Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study.
Kuijpers, Yunus Picavet, H Susan J de Rond, Lia de Zeeuw-Brouwer, Mary-Lène Rutkens, Ryanne Gijsbers, Esther Slits, Irene Engelfriet, Peter Buisman, Anne-Marie Verschuren, W M Monique
Kuijpers, Yunus
Picavet, H Susan J
de Rond, Lia
de Zeeuw-Brouwer, Mary-Lène
Rutkens, Ryanne
Gijsbers, Esther
Slits, Irene
Engelfriet, Peter
Buisman, Anne-Marie
Verschuren, W M Monique
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Open Access
Type
Article
Language
en
Date of publication
2023-10-25
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Potential determinants of antibody responses after vaccination against SARS-CoV-2 in older persons: the Doetinchem Cohort Study.
Translated Title
Published in
Immun Ageing 2023;20(1):57
Abstract
We included 1457 persons aged 50 to 92 years old. Of these persons 1257 were infection naïve after their primary vaccination series. The majority (N = 954) of these individuals were vaccinated with two doses of BNT162b2 (Pfizer) and their data were used for further analysis. A higher frailty index was associated with lower anti-S1 antibody responses at T1 and T2 for both men (RT1 = -0.095, PT1 = 0.05; RT2 = -0.11, PT2 = 0.02) and women (RT1 = -0.24, PT1 < 0.01; RT2 = -0.15, PT2 < 0.01). After correcting for age and sex the frailty index was also associated with the relative increase in anti-S1 IgG concentrations between the two vaccinations (β = 1.6, P < 0.01). Within the construct of frailty, history of a cardiac catheterization, diabetes, gastrointestinal disease, a cognitive speed in the lowest decile of the population distribution, and impaired lung function were associated with lower antibody responses after both vaccinations.