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Meningococcal serogroup C immunogenicity, antibody persistence and memory B-cells induced by the monovalent meningococcal serogroup C versus quadrivalent meningococcal serogroup ACWY conjugate booster vaccine: A randomized controlled trial.
van Ravenhorst, Mariƫtte B van der Klis, Fiona R M van Rooijen, Debbie M Knol, Mirjam J Stoof, Susanne P Sanders, Elisabeth A M Berbers, Guy A M
van Ravenhorst, Mariƫtte B
van der Klis, Fiona R M
van Rooijen, Debbie M
Knol, Mirjam J
Stoof, Susanne P
Sanders, Elisabeth A M
Berbers, Guy A M
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2017-08-24
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Meningococcal serogroup C immunogenicity, antibody persistence and memory B-cells induced by the monovalent meningococcal serogroup C versus quadrivalent meningococcal serogroup ACWY conjugate booster vaccine: A randomized controlled trial.
Translated Title
Published in
Vaccine 2017, 35(36):4745-52
Abstract
Adolescents are considered the key transmitters of meningococci in the population. Meningococcal serogroup C (MenC) antibody levels wane rapidly after MenC conjugate vaccination in young children, leaving adolescents with low antibody levels. In this study, we compared MenC immune responses after booster vaccination in adolescence with either tetanus toxoid conjugated MenC (MenC-TT) or MenACWY (MenACWY-TT) vaccine, and aimed to establish an optimal age for this booster.