Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.
Hullmann, Maja Albrecht, Catrin van Berlo, Damiën Gerlofs-Nijland, Miriam E Wahle, Tina Boots, Agnes W Krutmann, Jean Cassee, Flemming R Bayer, Thomas A Schins, Roel P F
Hullmann, Maja
Albrecht, Catrin
van Berlo, Damiën
Gerlofs-Nijland, Miriam E
Wahle, Tina
Boots, Agnes W
Krutmann, Jean
Cassee, Flemming R
Bayer, Thomas A
Schins, Roel P F
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Open Access
Type
Article
Language
en
Date of publication
2017-08-30
Year of publication
Research Projects
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Journal Issue
Title
Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.
Translated Title
Published in
Part Fibre toxicol 2017, 14(1):35
Abstract
Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urban environments, can aggravate Alzheimer's Disease (AD)-like effects in female 5X Familial AD (5XFAD) mice and their wild-type female littermates. Following 3 and 13 weeks exposures to diluted DEE (0.95 mg/m3, 6 h/day, 5 days/week) or clean air (controls) behaviour tests were performed and amyloid-β (Aβ) plaque formation, pulmonary histopathology and systemic inflammation were evaluated.