Stability and homogeneity of microbiological reference materials: some statistical models
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Series / Report no.
Open Access
Type
Report
Language
en
Date
1991-08-31
Research Projects
Organizational Units
Journal Issue
Title
Stability and homogeneity of microbiological reference materials: some statistical models
Translated Title
Stabiliteit en homogeniteit van microbiologisch referentiemateriaal: enkele statistische modellen
Published in
Abstract
Microbiological reference materials are being developed by the RIVM since several years. These materials consist of capsules filled with milkpowder artificially contaminated with a bacteria test strain of choice (i.e. Escherichia coli, Enterobacter cloacae, Salmonella typhimurium). Both from longterm stability tests, and from short-term challenge tests at different storage temperatures, it is clear that these materials cannot survive forever. Standard statistical techniques for quality control, assuming both a stable process and the Normal distribution cannot be used. In this report we will deal with these non-standard problems.<br>
Description
Publisher
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Sponsors
EG/BCR
HIMH
VHI
HIMH
VHI