Maternal measles antibodies and their influence on all-cause mortality following measles vaccination: an alternative to measure very low maternal antibody levels.
Smits, Gaby Stabell Benn, Christine Whittle, Hilton van Binnendijk, Rob Aaby, Peter van der Klis, Fiona
Smits, Gaby
Stabell Benn, Christine
Whittle, Hilton
van Binnendijk, Rob
Aaby, Peter
van der Klis, Fiona
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Title
Maternal measles antibodies and their influence on all-cause mortality following measles vaccination: an alternative to measure very low maternal antibody levels.
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Clin Infect Dis 2019; 68(10):1758-60
Abstract
It was previously shown by hemagglutination inhibition that measles-vaccination in the presence of maternal measles antibodies was associated with reduced all-cause mortality. We confirmed this serological association using a multiplexed immunoassay as a sensitive alternative and estimated a threshold concentration (28.7 mIU/ml), that correlates with lower all-cause mortality (p=0.02).