Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.
Seyed Khoei, Nazlisadat; Jenab, Mazda; Murphy, Neil; Banbury, Barbara L; Carreras-Torres, Robert; Viallon, Vivian; Kühn, Tilman; Bueno-de-Mesquita, Bas; Aleksandrova, Krasimira; Cross, Amanda J; Weiderpass, Elisabete; Stepien, Magdalena; Bulmer, Andrew; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Carbonnel, Franck; Katzke, Verena; Boeing, Heiner; Bergmann, Manuela M; Trichopoulou, Antonia; Karakatsani, Anna; Martimianaki, Georgia; Palli, Domenico; Tagliabue, Giovanna; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Skeie, Guri; Merino, Susana; Bonet, Catalina; Rodríguez-Barranco, Miguel; Gil, Leire; Chirlaque, Maria-Dolores; Ardanaz, Eva; Myte, Robin; Hultdin, Johan; Perez-Cornago, Aurora; Aune, Dagfinn; Tsilidis, Konstantinos K; Albanes, Demetrius; Baron, John A; Berndt, Sonja I; Bézieau, Stéphane; Brenner, Hermann; Campbell, Peter T; Casey, Graham; Chan, Andrew T; Chang-Claude, Jenny; Chanock, Stephen J; Cotterchio, Michelle; Gallinger, Steven; Gruber, Stephen B; Haile, Robert W; Hampe, Jochen; Hoffmeister, Michael; Hopper, John L; Hsu, Li; Huyghe, Jeroen R; Jenkins, Mark A; Joshi, Amit D; Kampman, Ellen; Larsson, Susanna C; Le Marchand, Loic; Li, Christopher I; Li, Li; Lindblom, Annika; Lindor, Noralane M; Martín, Vicente; Moreno, Victor; Newcomb, Polly A; Offit, Kenneth; Ogino, Shuji; Parfrey, Patrick S; Pharoah, Paul D P; Rennert, Gad; Sakoda, Lori C; Schafmayer, Clemens; Schmit, Stephanie L; Schoen, Robert E; Slattery, Martha L; Thibodeau, Stephen N; Ulrich, Cornelia M; van Duijnhoven, Franzel J B; Weigl, Korbinian; Weinstein, Stephanie J; White, Emily; Wolk, Alicja; Woods, Michael O; Wu, Anna H; Zhang, Xuehong; Ferrari, Pietro; Anton, Gabriele; Peters, Annette; Peters, Ulrike; Gunter, Marc J; Wagner, Karl-Heinz; Freisling, Heinz
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Open Access
Type
Article
Language
en
Date
2020-09-03
Research Projects
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Title
Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.
Translated Title
Published in
BMC Medicine 2020; 18(1):229
Abstract
In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC), pre-diagnostic unconjugated bilirubin (UCB, the main component of total bilirubin) concentrations were measured by high-performance liquid chromatography in plasma samples of 1386 CRC cases and their individually matched controls. Additionally, 115 single-nucleotide polymorphisms (SNPs) robustly associated (P < 5 × 10-8) with circulating total bilirubin were instrumented in a 2-sample MR to test for a potential causal effect of bilirubin on CRC risk in 52,775 CRC cases and 45,940 matched controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colon Cancer Family Registry (CCFR), and the Colorectal Transdisciplinary (CORECT) study.