Building a developmental toxicity ontology.
Baker, Nancy Boobis, Alan Burgoon, Lyle Carney, Edward Currie, Richard Fritsche, Ellen Knudsen, Thomas Laffont, Madeleine Piersma, Aldert H Poole, Alan
Baker, Nancy
Boobis, Alan
Burgoon, Lyle
Carney, Edward
Currie, Richard
Fritsche, Ellen
Knudsen, Thomas
Laffont, Madeleine
Piersma, Aldert H
Poole, Alan
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2018-01-31
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Building a developmental toxicity ontology.
Translated Title
Published in
Birth Defect Res 2018; 110(6):502-18
Abstract
As more information is generated about modes of action for developmental toxicity and more data are generated using high-throughput and high-content technologies, it is becoming necessary to organize that information. This report discussed the need for a systematic representation of knowledge about developmental toxicity (i.e., an ontology) and proposes a method to build one based on knowledge of developmental biology and mode of action/ adverse outcome pathways in developmental toxicity.