Poorly water soluble organic compounds: Guidance for the interpretation of results from aquatic ecotoxicity tests and a proposal for a modified classification and risk evaluation
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Open Access
Type
Report
Language
en
Date
1992-12-31
Research Projects
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Journal Issue
Title
Poorly water soluble organic compounds: Guidance for
the interpretation of results from aquatic ecotoxicity tests and a proposal
for a modified classification and risk evaluation
Translated Title
Slecht in water oplosbare organische stoffen:
Richtlijnen voor de interpretatie van resultaten afkomstig van aquatische
ecotoxicologische testen en een voorstel voor een gemodificeerde
classificatie en risico-evaluatie
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Abstract
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Circa 30% of the new substances that have to be notified for an evaluation of the potential hazards/risks have a poor water solubility (< 1mg/l). A problem is recognized in the interpretation of results of aquatic toxicity tests carried out with these compounds since the current OECD and EC guidelines give only little guidance to the testing of these compounds. This document intends to give guidance for the interpretation of results obtained from these tests for organic compounds. A modification of the current EC classification of compounds on the basis of environmental effects for the aquatic environment is proposed, based on the toxicity of a compound rather than on its water solubility. Some recommendations for the ecotoxicological risk evaluation of poorly water soluble compounds are presented.
Circa 30% of the new substances that have to be notified for an evaluation of the potential hazards/risks have a poor water solubility (< 1mg/l). A problem is recognized in the interpretation of results of aquatic toxicity tests carried out with these compounds since the current OECD and EC guidelines give only little guidance to the testing of these compounds. This document intends to give guidance for the interpretation of results obtained from these tests for organic compounds. A modification of the current EC classification of compounds on the basis of environmental effects for the aquatic environment is proposed, based on the toxicity of a compound rather than on its water solubility. Some recommendations for the ecotoxicological risk evaluation of poorly water soluble compounds are presented.
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