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Tetanus Toxoid carrier protein induced T-helper cell responses upon vaccination of middle-aged adults
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Series / Report no.
Open Access
Type
Article
Language
en
Date
2017-10-09
Research Projects
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Journal Issue
Title
Tetanus Toxoid carrier protein induced T-helper cell responses upon vaccination of middle-aged adults
Translated Title
Published in
Vaccine 2017, 35(42):5581-8
Abstract
Vaccines frequently induce suboptimal immune responses in the elderly, due to immunological ageing. Timely vaccination may be a strategy to overcome this problem, which classifies middle-aged adults asan interesting target group for future vaccine interventions. However, the immunological fitness of the middle-aged population is ill-defined. It is currently unknown whether effective T-cell help towards B-cells is initiated by conjugate-carrier vaccines at middle-age.