N-Nitrosodiethanolamine (NDELA) in cosmetica methode ontwikkeling en monster analyse
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Open Access
Type
Report
Language
nl
Date
1997-09-30
Research Projects
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Journal Issue
Title
N-Nitrosodiethanolamine (NDELA) in cosmetica methode
ontwikkeling en monster analyse
Translated Title
N-Nitrosodiethanolamine (NDELA) in cosmetics
method development and sample analysis
Published in
Abstract
In 1995 is op verzoek van de Inspectie Gezondheids
Bescherming de N-nitrosamine problematiek in cosmetische producten in kaart
gebracht. Voor het bepalen van NDELA in cosmetica is de GC-TEA methode
ontwikkeld en gevalideerd. De terugwinning voor NDELA is gemiddeld 99%
(N=4) en de bepaalbaarheidsgrens is 5 mug NDELA / kg cosmetica. De GC-TEA
methode is gebruikt om in 48 cosmetische producten, waaronder shampoos,
cremes, melk , conditioners en schuimen het NDELA gehalte te bepalen. Alle
bepalingen werden in tweevoud uitgevoerd en voor elke 10 cosmetica monsters
is een terugwinnings- en blanco-experiment uitgevoerd. De resultaten van
deze kwaliteitsexperimenten voldeden aan de kwaliteitskenmerken van de
ontwikkelde methode.Van de 48 onderzochte monsters cosmetica bevatten vier
monsters meetbare hoeveelheden NDELA.
In response to the 1995 review of the N-nitrosamine problem in cosmetics at the request of the Inspectorate of Health Protection (IGB), a GC-TEA method for determining NDELA in cosmetics has been developed and validated. In a sample diluted with water, adsorbed onto a kieselguhr column and eluted with n-butanol, the average recovery for NDELA is 99% (N=4) and the limit of quantification 5 mug/kg. The GC-TEA method described was used to determine the NDELA content of 48 cosmetics including gels, shampoos, cremes, milks, conditioners and foams. All determinations were done in duplicate and for every 10 cosmetics a recovery experiment and a blank determination were performed. The results of these quality assurance experiments were within the performance characteristics of the method developed. Amounts of NDELA above the limit of quantification of 5 mug/kg were measured in 4 out of the 48 cosmetics.
In response to the 1995 review of the N-nitrosamine problem in cosmetics at the request of the Inspectorate of Health Protection (IGB), a GC-TEA method for determining NDELA in cosmetics has been developed and validated. In a sample diluted with water, adsorbed onto a kieselguhr column and eluted with n-butanol, the average recovery for NDELA is 99% (N=4) and the limit of quantification 5 mug/kg. The GC-TEA method described was used to determine the NDELA content of 48 cosmetics including gels, shampoos, cremes, milks, conditioners and foams. All determinations were done in duplicate and for every 10 cosmetics a recovery experiment and a blank determination were performed. The results of these quality assurance experiments were within the performance characteristics of the method developed. Amounts of NDELA above the limit of quantification of 5 mug/kg were measured in 4 out of the 48 cosmetics.
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