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Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies.
Watts, Eleanor L; Appleby, Paul N; Perez-Cornago, Aurora; Bueno-de-Mesquita, H Bas; Chan, June M; Chen, Chu; Cohn, Barbara A; Cook, Michael B; Flicker, Leon; Freedman, Neal D; Giles, Graham G; Giovannucci, Edward; Gislefoss, Randi E; Hankey, Graeme J; Kaaks, Rudolf; Knekt, Paul; Kolonel, Laurence N; Kubo, Tatsuhiko; Le Marchand, Loïc; Luben, Robert N; Luostarinen, Tapio; Männistö, Satu; Metter, E Jeffrey; Mikami, Kazuya; Milne, Roger L; Ozasa, Kotaro; Platz, Elizabeth A; Quirós, J Ramón; Rissanen, Harri; Sawada, Norie; Stampfer, Meir; Stanczyk, Frank Z; Stattin, Pär; Tamakoshi, Akiko; Tangen, Catherine M; Thompson, Ian M; Tsilidis, Konstantinos K; Tsugane, Shoichiro; Ursin, Giske; Vatten, Lars; Weiss, Noel S; Yeap, Bu B; Allen, Naomi E; Key, Timothy J; Travis, Ruth C
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Open Access
Type
Article
Language
en
Date
2018-08-01
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Title
Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies.
Translated Title
Published in
Eur Urol 2018; 74(5):585-94
Abstract
Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting.