Statistische analyse van een subchronisch toxicologisch experiment
Pijls JWAM Hoekstra JA
Pijls JWAM
Hoekstra JA
Citations
Altmetric:
Series / Report no.
Open Access
Type
Report
Language
nl
Date of publication
1990-04-30
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Statistische analyse van een subchronisch
toxicologisch experiment
Translated Title
The statistical analysis of a subchronic toxicity
experiment
Published in
Abstract
Abstract niet beschikbaar
This report presents a statistical analysis of an investigation into the subchronic toxicity of patulin in rats. The method used is analysis of variance with explanatory factors 'concentration of patulin' and 'sex'. The factor 'concentration' was split into (orthogonal) polynomials. The resulting regression model can be used to estimate concentrations that have a toxic effect of a given magnitude, with confidence limits. The lower limit of one such estimate can be used for regulatory purposes, as an alternative tot the NOEC-value. The effects of patulin on the creatinin clearance and feed conversion are described. Finally, recommendations are given with respect to the design of toxicological experiments in general.
This report presents a statistical analysis of an investigation into the subchronic toxicity of patulin in rats. The method used is analysis of variance with explanatory factors 'concentration of patulin' and 'sex'. The factor 'concentration' was split into (orthogonal) polynomials. The resulting regression model can be used to estimate concentrations that have a toxic effect of a given magnitude, with confidence limits. The lower limit of one such estimate can be used for regulatory purposes, as an alternative tot the NOEC-value. The effects of patulin on the creatinin clearance and feed conversion are described. Finally, recommendations are given with respect to the design of toxicological experiments in general.
Description
Publisher
Sponsors
HIGB