It Takes Two to Tango: Combining Conventional Culture With Molecular Diagnostics Enhances Accuracy of Detection and Pneumococcal Serogroup/Serotype Determination in Carriage.
Miellet, Willem R; van Veldhuizen, Janieke; Litt, David; Mariman, Rob; Wijmenga-Monsuur, Alienke J; Badoux, Paul; Nieuwenhuijsen, Tessa; Thombre, Rebecca; Mayet, Sanaa; Eletu, Seyi; Sheppard, Carmen; van Houten, Marianne Alice; Rots, Nynke Y; Miller, Elizabeth; Fry, Norman K; Sanders, Elisabeth A M; TrzciĆski, Krzysztof
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Open Access
Type
Article
Language
en
Date
2022-04-18
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Title
It Takes Two to Tango: Combining Conventional Culture With Molecular Diagnostics Enhances Accuracy of Detection and Pneumococcal Serogroup/Serotype Determination in Carriage.
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Published in
Frontiers in microbiology 2022;13:859736
Abstract
The specificity of molecular methods for the detection of Streptococcus pneumoniae carriage is under debate. We propose a procedure for carriage surveillance and vaccine impact studies that increases the accuracy of molecular detection of live pneumococci in polymicrobial respiratory samples.