It Takes Two to Tango: Combining Conventional Culture With Molecular Diagnostics Enhances Accuracy of Detection and Pneumococcal Serogroup/Serotype Determination in Carriage.
Miellet, Willem R van Veldhuizen, Janieke Litt, David Mariman, Rob Wijmenga-Monsuur, Alienke J Badoux, Paul Nieuwenhuijsen, Tessa Thombre, Rebecca Mayet, Sanaa Eletu, Seyi
Miellet, Willem R
van Veldhuizen, Janieke
Litt, David
Mariman, Rob
Wijmenga-Monsuur, Alienke J
Badoux, Paul
Nieuwenhuijsen, Tessa
Thombre, Rebecca
Mayet, Sanaa
Eletu, Seyi
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2022-04-18
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
It Takes Two to Tango: Combining Conventional Culture With Molecular Diagnostics Enhances Accuracy of Detection and Pneumococcal Serogroup/Serotype Determination in Carriage.
Translated Title
Published in
Frontiers in microbiology 2022;13:859736
Abstract
The specificity of molecular methods for the detection of Streptococcus pneumoniae carriage is under debate. We propose a procedure for carriage surveillance and vaccine impact studies that increases the accuracy of molecular detection of live pneumococci in polymicrobial respiratory samples.