Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.
Zheng, Ju-Sheng; Luan, Jian'an; Sofianopoulou, Eleni; Imamura, Fumiaki; Stewart, Isobel D; Day, Felix R; Pietzner, Maik; Wheeler, Eleanor; Lotta, Luca A; Gundersen, Thomas E; Amiano, Pilar; Ardanaz, Eva; Chirlaque, María-Dolores; Fagherazzi, Guy; Franks, Paul W; Kaaks, Rudolf; Laouali, Nasser; Mancini, Francesca Romana; Nilsson, Peter M; Onland-Moret, N Charlotte; Olsen, Anja; Overvad, Kim; Panico, Salvatore; Palli, Domenico; Ricceri, Fulvio; Rolandsson, Olov; Spijkerman, Annemieke M W; Sánchez, María-José; Schulze, Matthias B; Sala, Núria; Sieri, Sabina; Tjønneland, Anne; Tumino, Rosario; van der Schouw, Yvonne T; Weiderpass, Elisabete; Riboli, Elio; Danesh, John; Butterworth, Adam S; Sharp, Stephen J; Langenberg, Claudia; Forouhi, Nita G; Wareham, Nicholas J
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Open Access
Type
Article
Language
en
Date
2020-11-17
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Title
Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.
Translated Title
Published in
Diabetes Care 2021; 44(1):98-106
Abstract
We identified 11 genomic regions associated with plasma vitamin C (P < 5 × 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its apparent pleiotropic effect) and type 2 diabetes (1.03; 95% CI 0.96, 1.10).