The half-life of maternal transplacental antibodies against diphtheria, tetanus, and pertussis in infants: an individual participant data meta-analysis.
Oguti, Blanché; Ali, Asad; Andrews, Nick; Barug, Daan; Anh Dang, Duc; Halperin, Scott A; Thu Hoang, Ha Thi; Holder, Beth; Kampmann, Beate; Kazi, Abdul M; Langley, Joanne M; Leuridan, Elke; Madavan, Naomi; Maertens, Kirsten; Maldonado, Herberth; Miller, Elizabeth; Munoz-Rivas, Flor M; Omer, Saad B; Pollard, Andrew J; Rice, Thomas F; Rots, Nynke; Sundaram, Maria E; Wanlapakorn, Nasamon; Voysey, Merryn
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Series / Report no.
Open Access
Type
Article
Language
en
Date
2021-12-21
Research Projects
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Title
The half-life of maternal transplacental antibodies against diphtheria, tetanus, and pertussis in infants: an individual participant data meta-analysis.
Translated Title
Published in
Vaccine 2021; Online ahead of print
Abstract
De-identified data from infants born to women taking part in 10 studies, in 9 countries (UK, Belgium, Thailand, Vietnam, Canada, Pakistan, USA, Guatemala and the Netherlands) were combined in an individual participant data meta-analysis. Blood samples were taken at two timepoints before any DTP-containing vaccines were received by the infant: at birth and at 2-months of age. Decay rates for each antigen were log2-transformed and a mixed effects model was applied. Half-lives were calculated by taking the reciprocal of the absolute value of the mean decay rates.