Onderzoek naar de mutagene werking van 4-amino-bifenyl en van enkele intermediairen van de stofwisseling alsmede enkele 3-methylderivaten op microorganismen
Citations
Altmetric:
Series / Report no.
Open Access
Type
Report
Language
nl
Date
1992-05-31
Research Projects
Organizational Units
Journal Issue
Title
Onderzoek naar de mutagene werking van
4-amino-bifenyl en van enkele intermediairen van de stofwisseling alsmede
enkele 3-methylderivaten op microorganismen
Translated Title
The mutagenic activity of 4-amino-biphenyl and
some intermediaries of metabolism and some 3-methyl-derivatives on
micro-organisms
Published in
Abstract
Abstract niet beschikbaar
The mutagenic activity of 4-aminobiphenyl and 4-amino-3-methylbiphenyl was investigated in the Amestest, Salmonella typhimurium strains TA100 and TA98 were used. 4-N-acetylaminobiphenyl and 4-N-acetylamino-3- methylbiphenyl were not mutagenic (or weakly). 4-Amonibiphenyl, 4-amino-3-methyl-biphenyl, 4-acetoxy-acetylaminobiphenyl, 4-N-hydroxy-N-acetylaminobiphenyl and 4-N-hydroxy-N-acetylamino- 3-methylbiphenyl were mutagenic in the presence of metabolic activation. With 4-hydroxylaminobiphenyl, 3-methyl-4-hydroxylaminobiphenyl and 3-methyl-4-acetoxy-acetylaminobiphenyl a mutagenic activity was found in the presence and absence of metabolic activation. With 4-nitrobiphenyl and 3-methyl-4-nitrobiphenyl a mutagenic activity was found without metabolic activation. The obtained results point to the hydroxylamino derivatives as being the ultimate mutagenic derivatives of 4-aminobiphenyl and 4-amino-3-methylbiphenyl.
The mutagenic activity of 4-aminobiphenyl and 4-amino-3-methylbiphenyl was investigated in the Amestest, Salmonella typhimurium strains TA100 and TA98 were used. 4-N-acetylaminobiphenyl and 4-N-acetylamino-3- methylbiphenyl were not mutagenic (or weakly). 4-Amonibiphenyl, 4-amino-3-methyl-biphenyl, 4-acetoxy-acetylaminobiphenyl, 4-N-hydroxy-N-acetylaminobiphenyl and 4-N-hydroxy-N-acetylamino- 3-methylbiphenyl were mutagenic in the presence of metabolic activation. With 4-hydroxylaminobiphenyl, 3-methyl-4-hydroxylaminobiphenyl and 3-methyl-4-acetoxy-acetylaminobiphenyl a mutagenic activity was found in the presence and absence of metabolic activation. With 4-nitrobiphenyl and 3-methyl-4-nitrobiphenyl a mutagenic activity was found without metabolic activation. The obtained results point to the hydroxylamino derivatives as being the ultimate mutagenic derivatives of 4-aminobiphenyl and 4-amino-3-methylbiphenyl.
Description
Publisher
Sponsors
HIGB