Study to investigate the difference in reaction to intracutaneously and orally administered histamine between suspected histamine-intolerant patients and healthy volunteers
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Series / Report no.
Open Access
Type
Report
Language
en
Date
1996-04-30
Research Projects
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Journal Issue
Title
Study to investigate the difference in reaction to intracutaneously and orally administered histamine between suspected histamine-intolerant patients and healthy volunteers
Translated Title
Onderzoek naar de effecten van histamine op gezonde vrijwilligers en histamine-intolerante patienten
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Abstract
In een dubbelblinde placebo gecontroleerde, vergelijkende studie werd aan 16 histamine intolerante patienten en aan 16 gezonde proefpersonen histamine toegediend. Het doel van de studie was het ontwikkelen van een relatief simpele en betrouwbare test voor het stellen van de diagnose histamine-intolerantie onder de aanname dat histamine-intolerante patienten, gastro-intestinaal, een reletief tekort aan het enzym diamine oxidase (DAO) hebben. Histamine werd zowel intracutaan als oraal toegediend. Bijwerkingen werden geregistreerd, de bloeddruk gemeten en bloed en urine verzameld. In het bloed werd de concentratie histamine en methylhistamine gemeten. In de urine werden N-methyl-imidazol-azijnzuur en N-methylhistamine bepaald. Noch intracutane toediening van histamine, noch orale toediening van histamine kan vooralsnog gebruikt worden als valide test om histamine-intolerantie te diagnostiseren, aangezien voor geen enkele parameter significante verschillen zijn gevonden tussen patienten en vrijwilligers.<br>
A study, designed as a double-blind placebo controlled comparative study, has been performed in order to investigate the difference in reaction to intracutaneously and orally administered histamine between patients and healthy volunteers based on the assumption that histamine-intolerant patients have a relative shortage of the enzyme diamine-oxidase (DAO). Several parameters were determined in patients and compared to those in healthy volunteers. No statistical significant differences were found between patients and healthy volunteers after intracutaneous and oral administration of histamine. It can, therefore, be concluded that neither intracutaneous nor oral administration of histamine can as yet be used as a valid test to diagnose histamine-intolerance.<br>
A study, designed as a double-blind placebo controlled comparative study, has been performed in order to investigate the difference in reaction to intracutaneously and orally administered histamine between patients and healthy volunteers based on the assumption that histamine-intolerant patients have a relative shortage of the enzyme diamine-oxidase (DAO). Several parameters were determined in patients and compared to those in healthy volunteers. No statistical significant differences were found between patients and healthy volunteers after intracutaneous and oral administration of histamine. It can, therefore, be concluded that neither intracutaneous nor oral administration of histamine can as yet be used as a valid test to diagnose histamine-intolerance.<br>
Description
Publisher
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Sponsors
HIGB
UU/vakgroep Dermatologie-Allergologie en vakgroep Reanimatie en Toxicologie van de Universiteit Utrecht
UU/vakgroep Dermatologie-Allergologie en vakgroep Reanimatie en Toxicologie van de Universiteit Utrecht