Effecten van anaesthetica op de vroege ontwikkeling van de geslachtscellen van de rat
Garbis-Berkvens JM Hofstee-Hooftman MWA Verhoef A Piersma AH Peters PWJ Koeter HBWM
Garbis-Berkvens JM
Hofstee-Hooftman MWA
Verhoef A
Piersma AH
Peters PWJ
Koeter HBWM
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Series / Report no.
Open Access
Type
Report
Language
nl
Date of publication
1991-02-28
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Effecten van anaesthetica op de vroege ontwikkeling van de geslachtscellen van de rat
Translated Title
Effects of anaesthetics on the early development of primordial germ cells in the rat
Published in
Abstract
The effects of prenatal exposure to anaesthetics on the early development of primordial germ cells were studied in the rat. The study consisted of 4 treatment groups: control, low and high dose of halothane + nitrous oxide and galactose as a positive control. Histological and semiquantitative studies of the gonads were performed at day 14 and 21 post coitum. They did not reveal any effect of anaesthetics on the germ cell development of the rat. In the galactose group decreased numbers of germ cells were seen as a result of general growth retardation. The results are described and discussed in view of literature data. This study was part of an experiment designed to study the effects of anaesthetics on reproduction and on pre- and postnatal development in the rat.<br>
Description
Publisher
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Sponsors
SW/DGA
TNO/CIVO
RIVM
TNO/CIVO
RIVM