Effect of C reactive protein point-of-care testing on antibiotic prescribing for lower respiratory tract infections in nursing home residents: cluster randomised controlled trial.
Boere, Tjarda M van Buul, Laura W Hopstaken, Rogier M van Tulder, Maurits W Twisk, Jos W M R Verheij, Theo J M Hertogh, Cees M P M
Boere, Tjarda M
van Buul, Laura W
Hopstaken, Rogier M
van Tulder, Maurits W
Twisk, Jos W M R
Verheij, Theo J M
Hertogh, Cees M P M
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Series / Report no.
Open Access
Type
Article
Other
Other
Language
en
Date of publication
2021-09-21
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Effect of C reactive protein point-of-care testing on antibiotic prescribing for lower respiratory tract infections in nursing home residents: cluster randomised controlled trial.
Translated Title
Published in
BMJ 2021; 374:n2198
Abstract
Antibiotics were prescribed at initial consultation for 84 (53.5%) patients in the intervention group and 65 (82.3%) in the control group. Patients in the intervention group had 4.93 higher odds (95% confidence interval 1.91 to 12.73) of not being prescribed antibiotics at initial consultation compared with the control group, irrespective of treating physician and baseline characteristics. The between group difference in antibiotic prescribing at any point from initial consultation to follow-up was 23.6%. Differences in secondary outcomes between the intervention and control groups were 4.4% in full recovery rates at three weeks (86.4% v 90.8%), 2.2% in all cause mortality rates (3.5% v 1.3%), and 0.7% in hospital admission rates (7.2% v 6.5%). The odds of full recovery at three weeks, and the odds of mortality and hospital admission at any point did not significantly differ between groups.