OECD 28-days oral toxicity study on fumonisin B1
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Series / Report no.
Open Access
Type
Report
Language
en
Date
1999-02-01
Research Projects
Organizational Units
Journal Issue
Title
OECD 28-days oral toxicity study on fumonisin
B1
Translated Title
OECD 28-daagse orale toxiciteitsstudie fumonisine
B1
Published in
Abstract
Het beschreven experiment werd uitgevoerd om inzicht te
verkrijgen over effecten van lage doseringen fumonisine B1 op target organen
en het immuunsysteem. Mannelijke ratten van drie weken oud werden oraal via
maagsonde behandeld met 0, 0,19, 0,75 of 3 mg/kg lichaamsgewicht fumonisine
B1, dagelijks gedurende vier weken. Op dag 28 na het begin van de
behandeling werd sectie verricht en een aantal toxicologische parameters,
inclusief immunotoxicologische parameters, werd bepaald. In het bloed
werden biochemische bepalingen uitgevoerd, terwijl in het bloed en ook in de
lever en nier sphingolipiden werden bepaald. De resultaten van dit
experiment gaven aan dat nier- en leverweefsel de primaire targetorganen
voor toxiciteit van lage doseringen fumonisine B1 zijn. Blootstelling aan
lage doseringen fumonisine B1 induceert en continueert celproliferatie in
niertubuli, hetgeen aanleiding kan geven tot tumorvorming. In het
immuunsysteem werden geen significante effecten waargenomen, al werden wel
trends gezien. In het licht van gepubliceerde immunotoxische effecten van
fumonisine B1 is m.n. aan dit aspect verder onderzoek
nodig
The experiment described was carried out to gain knowledge on the effects of low doses of fumonisin B1 on target organs and the immune system. Male rats (age three weeks) received oral (gavage) doses of 0, 0.19, 0.75 or 3 mg fumonisin B1 kg-1 body weight (BW) (dissolved in water) daily for four weeks. After 28 days of treatment, the animals were sacrificed and necropsied. Blood collected during necropsy was used for biochemical analysis. Additional blood and tissue from liver and kidney were collected for sphingolipid analysis. The presented study showed that the kidney and liver are the prime target organs for toxicity of low doses fumonisin B1. Exposure to low levels of fumonisin B1 induced continuous cell proliferation in the kidney tubules which might eventually result in tumour alterations in the proliferating cells. No clear effects on the immune system were observed. However, when combining the observed trends in this experiment with the results from other published experiments on the parameters of the immune system, potential immunotoxicity of fumonisin B1 cannot be ruled out. Further research needs to be carried out.
The experiment described was carried out to gain knowledge on the effects of low doses of fumonisin B1 on target organs and the immune system. Male rats (age three weeks) received oral (gavage) doses of 0, 0.19, 0.75 or 3 mg fumonisin B1 kg-1 body weight (BW) (dissolved in water) daily for four weeks. After 28 days of treatment, the animals were sacrificed and necropsied. Blood collected during necropsy was used for biochemical analysis. Additional blood and tissue from liver and kidney were collected for sphingolipid analysis. The presented study showed that the kidney and liver are the prime target organs for toxicity of low doses fumonisin B1. Exposure to low levels of fumonisin B1 induced continuous cell proliferation in the kidney tubules which might eventually result in tumour alterations in the proliferating cells. No clear effects on the immune system were observed. However, when combining the observed trends in this experiment with the results from other published experiments on the parameters of the immune system, potential immunotoxicity of fumonisin B1 cannot be ruled out. Further research needs to be carried out.
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