Toxicology and occurrence of nivalenol, fusarenon X, diacetoxyscirpenol, neosolaniol and 3- and 15- acetyldeoxynivalenol; a review of six trichothecenes
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Series / Report no.
Open Access
Type
Report
Language
en
Date
2002-11-07
Research Projects
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Journal Issue
Title
Toxicology and occurrence of nivalenol, fusarenon X, diacetoxyscirpenol, neosolaniol and 3- and 15- acetyldeoxynivalenol; a review of six trichothecenes
Translated Title
Toxicologie en voorkomen van nivalenol, fusarenon X, diacetoxyscirpenol, neosolaniol en 3- and 15- acetyldeoxynivalenol; een overzicht van 6 trichothecenen
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Abstract
Om de potentiele effecten vast te stellen van de trichothecenen nivalenol (NIV), fusarenon X (FusX), diacetoxyscirpenol (DAS), neosolaniol (NeoSol) en 3- and 15-acetyldeoxynivalenol (3-Ac-DON, 15-Ac-DON), werden toxiciteitsdata geevalueerd, om waar mogelijk "tolerable daily intakes'(TDIs) vast te stellen. Ook werd hun voorkomen in granen, veevoer en voedingsmiddelen onderzocht. De zes trichothecenen zijn mycotoxinen, geproduceerd door Fusarium soorten. NIV werd het vaakst aangetroffen in voedingsmiddelen. Het voorkomen van FusX, DAS, NeoSol en 3- en 15-Ac-DON werd zelden gerapporteerd, zeer waarschijnlijk omdat er niet routinematig op werd onderzocht. Derhalve werd aanbevolen meer aandacht te schenken aan FusX, DAS, NeoSol en 3- en 15-Ac-DON in routine-onderzoeksprogramma's. De toxiciteitsdata beschikbaar over FusX, DAS, NeoSol en 3- en 15-Ac-DON waren te beperkt om TDIs af te leiden. Alleen voor NIV waren voldoende toxiciteitsgegevens beschikbaar om een tijdelijke TDI van 0.7 ug/kg af te leiden.<br>
To assess the potential health effects of the xyscirpenol (DAS), neosolaniol (NeoSol) and 3- and 15-acetyldeoxynivalenol (3-Ac-DON, 15-Ac-DON), toxicology data available on these compounds were reviewed to derive, where possible, tolerable daily intakes (TDIs). Also, their occurrence in cereal grains, animal feed and human foodstuffs was investigated. The six trichothecenes are mycotoxins produced by Fusarium spp. NIV was the one most often found in food commodities. FusX, DAS, NeoSol and 3- and 15-Ac-DON have rarely been reported to occur, most likely because they were not routinely monitored for. It was therefore recommended to pay more attention to FusX, DAS, NeoSol and 3- and 15-Ac-DON in routine monitoring programs. The toxicology data available on FusX, DAS, 3-Ac-DON, 15-Ac-DON and NeoSol were too limited to derive TDIs. Only for NIV sufficient toxicology data were available to derive a temporary TDI of 0.7 ug/kg bw.<br>
To assess the potential health effects of the xyscirpenol (DAS), neosolaniol (NeoSol) and 3- and 15-acetyldeoxynivalenol (3-Ac-DON, 15-Ac-DON), toxicology data available on these compounds were reviewed to derive, where possible, tolerable daily intakes (TDIs). Also, their occurrence in cereal grains, animal feed and human foodstuffs was investigated. The six trichothecenes are mycotoxins produced by Fusarium spp. NIV was the one most often found in food commodities. FusX, DAS, NeoSol and 3- and 15-Ac-DON have rarely been reported to occur, most likely because they were not routinely monitored for. It was therefore recommended to pay more attention to FusX, DAS, NeoSol and 3- and 15-Ac-DON in routine monitoring programs. The toxicology data available on FusX, DAS, 3-Ac-DON, 15-Ac-DON and NeoSol were too limited to derive TDIs. Only for NIV sufficient toxicology data were available to derive a temporary TDI of 0.7 ug/kg bw.<br>
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Publisher
Rijksinstituut voor Volksgezondheid en Milieu RIVM
Sponsors
KvW