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Temporal associations between national outbreaks of meningococcal serogroup W and C disease in the Netherlands and England: an observational cohort study.
Knol, Mirjam J Hahné, Susan J M Lucidarme, Jay Campbell, Helen de Melker, Hester E Gray, Stephen J Borrow, Ray Ladhani, Shamez N Ramsay, Mary E van der Ende, Arie
Knol, Mirjam J
Hahné, Susan J M
Lucidarme, Jay
Campbell, Helen
de Melker, Hester E
Gray, Stephen J
Borrow, Ray
Ladhani, Shamez N
Ramsay, Mary E
van der Ende, Arie
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Open Access
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Article
Language
en
Date of publication
2017-10
Year of publication
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Title
Temporal associations between national outbreaks of meningococcal serogroup W and C disease in the Netherlands and England: an observational cohort study.
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Lancet Public Health 2017; 2(10):e473-82
Abstract
Since 2009, the incidence of meningococcal serogroup W disease has increased rapidly in the UK because of a single strain (the so-called original UK strain) belonging to the hypervirulent sequence type-11 clonal complex (cc11), with a variant outbreak strain (the so-called 2013 strain) emerging in 2013. Subsequently, the Netherlands has had an increase in the incidence of meningococcal serogroup W disease. We assessed the temporal and phylogenetic associations between the serogroup W outbreaks in the Netherlands and England, and the historical serogroup C outbreaks in both countries.