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Epidemiological links between tuberculosis cases identified twice as efficiently by whole genome sequencing than conventional molecular typing: A population-based study.
Jajou, Rana Neeling, Albert de Hunen, Rianne van Vries, Gerard de Schimmel, Henrieke Mulder, Arnout Anthony, Richard Hoek, Wim van der Soolingen, Dick van
Jajou, Rana
Neeling, Albert de
Hunen, Rianne van
Vries, Gerard de
Schimmel, Henrieke
Mulder, Arnout
Anthony, Richard
Hoek, Wim van der
Soolingen, Dick van
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2018
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Epidemiological links between tuberculosis cases identified twice as efficiently by whole genome sequencing than conventional molecular typing: A population-based study.
Translated Title
Published in
Plos One 2018; 13(4):e0195413
Abstract
Patients with Mycobacterium tuberculosis isolates sharing identical DNA fingerprint patterns can be epidemiologically linked. However, municipal health services in the Netherlands are able to confirm an epidemiological link in only around 23% of the patients with isolates clustered by the conventional variable number of tandem repeat (VNTR) genotyping. This research aims to investigate whether whole genome sequencing (WGS) is a more reliable predictor of epidemiological links between tuberculosis patients than VNTR genotyping.