Are metabolic signatures mediating the relationship between lifestyle factors and hepatocellular carcinoma risk? Results from a nested case-control study in EPIC.
Assi, Nada Thomas, Duncan C Leitzman, Michael Stepien, Magdalena Chajes, Veronique Philip, Thierry Vineis, Paolo Bamia, Christina Boutron-Ruault, Marie-Christine Sandanger, Torkjel M
Assi, Nada
Thomas, Duncan C
Leitzman, Michael
Stepien, Magdalena
Chajes, Veronique
Philip, Thierry
Vineis, Paolo
Bamia, Christina
Boutron-Ruault, Marie-Christine
Sandanger, Torkjel M
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Series / Report no.
Open Access
Type
Article
Language
en
Date of publication
2018-03-21
Year of publication
Research Projects
Organizational Units
Journal Issue
Title
Are metabolic signatures mediating the relationship between lifestyle factors and hepatocellular carcinoma risk? Results from a nested case-control study in EPIC.
Translated Title
Published in
Cancer Epidemiol Biomarkers Prev 2018; 27(5):531-40
Abstract
The "meeting-in-the-middle" (MITM) is a principle to identify exposure biomarkers that are also predictors of disease. The MITM statistical framework was applied in a nested case-control study of hepatocellular carcinoma (HCC) within EPIC where healthy lifestyle index (HLI) variables were related to targeted serum metabolites.