Nasopharyngeal microbiota in children is associated with severe asthma exacerbations
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Open Access
Type
Article
Language
en
Date
2024-03-10
Research Projects
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Journal Issue
Title
Nasopharyngeal microbiota in children is associated with severe asthma exacerbations
Translated Title
Published in
J Allergy Clin Immunol 2024; 153(6):1574-1585.e14
Abstract
Cases showed higher Shannon diversity index (ICU and MCU combined; P = .002) and a distinct microbial community composition when compared with controls (permutational multivariate ANOVA R2 = 1.9%; P < .001). We observed significantly higher abundance of Staphylococcus and "oral" taxa, including Neisseria, Veillonella, and Streptococcus spp. and a lower abundance of Dolosigranulum pigrum, Corynebacterium, and Moraxella spp. (MaAsLin2; q < 0.25) in cases versus controls. Furthermore, Neisseria abundance was associated with more severe disease (ICU vs MCU MaAslin2, P = .03; q = 0.30). Neisseria spp. abundance was also related with fine particulate matter exposure, whereas Haemophilus and Streptococcus abundances were related with recent inhaled corticosteroid use. We observed no correlations with viral infection.